Mattosinhos, P. d. S., Sarandy, M. M., Novaes, R. D., Esposito, D., Gonçalves, R. V. (2022). Anti-Inflammatory, Antioxidant, and Skin Regenerative
Potential of Secondary Metabolites from Plants of the Brassicaceae Family: A Systematic Review of In Vitro and In Vivo Preclinical Evidence (Biological Activities Brassicaceae Skin Diseases). Antioxidants, 11(7), 1346.

Gonçalves, R. V., Freitas, M. B., Esposito, D. (2022). Cellular and Molecular Mechanisms of Oxidative Stress in Wound Healing. Oxidative Medicine and Cellular Longevity.

Gonçalves, R. V., Sarandy, M. M., Esposito, D., & do Carmo Gouveia Peluzio, M. (2022). Mechanisms, Biomarkers, and Therapeutics Involved in
Inflammatory Disorders and Tissue Repair 2021. Oxidative Medicine and Cellular Longevity, 2022.

Rathinasabapathy, T., Lomax, J., Srikanth, K., Esposito, D., Kay, C. D., & Komarnytsky, S. (2022). Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro. Immuno2(2), 293-306.


Esposito LGA, Overbaugh E, Xiong J, Rathinasabapathy T, Komarnytsky S, da Silva DJH, Esposito DA. Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants. Immuno. 2021; 1(4):369-379.

Xiong J, Bonney S, Matta FV, Thompson N, Esposito D (2021). Effects of Dietary Supplementation with Cabbage Extract on Brain Mineral Compositions and Inflammatory Marker Expressions in SAMP8 Mice. In Vitro Cellular & Developmental Biology-Animal 2021 Jun 1 (Vol. 57, No. Suppl 1, pp. S46-S46). One New York Plaza, Suite 4600, NY, United States: Springer.

Thompson N, Xiong J, Bonney S, Matta FV, Esposito D (2021). Protective Effects of Blackcurrant Extract in Senescence Accelerated Mouse (SAMP8) Models. In Vitro Cellular & Developmental Biology-Animal 2021 Jun 1 (Vol. 57, No. Suppl 1, pp. S33-S34). One New York Plaza, Suite 4600, NY, United States: Springer.


Nogueira BC, Campos AK, Alves RS, Sarandy MM, Novaes RD, Esposito D, Gonçalves RV. What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence. Oxidative Medicine and Cellular Longevity. 2020 Dec 7; 2020.

Matta FV, Xiong J, Lila MA, Ward NI, Felipe-Sotelo M, Esposito D. Chemical composition and bioactive properties of commercial and non-commercial purple and white açaí berries.Foods. 2020 Oct, 9(10):1481.

Di, R., Murray, A. F., Xiong, J., Esposito, D., Komarnytsky, S., Gianfagna, T. J., & Munafo Jr, J. P. (2020). Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts. Journal of Ethnopharmacology.

Lall, N., Mahomoodally, F. M., Esposito, D., Steenkamp, V., Zengin, G., Steyn, A., & Oosthuizen, C. B. (2020). Cosmeceuticals from Medicinal Plants. Frontiers in Pharmacology11, 1149.

Xiong, J., Matta, F. V., Grace, M., Lila, M. A., Ward, N. I., Felipe-Sotelo, M., & Esposito, D. (2020). Phenolic content, anti-inflammatory, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon. Food & Function.

Moraes F, Xiong J, Borges K, Hoskin RT, Esposito, D (2020). Phytochemical content, antioxidant, anti-inflammatory activities and wound healing properties of freeze-dried fruits. Acta Scientific Nutritional Health, 4(1), 63-71.


Walter, K.R., Lin, X., Jacobi, S.K., Käser, T., Esposito, D. and Odle, J., (2019). Dietary arachidonate in milk replacer triggers dual benefits of PGE 2 signaling in LPS-challenged piglet alveolar macrophages. Journal of animal science and biotechnology, 10(1), p.13.

Esposito, D., Overall, J., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2019). Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling. FRONTIERS IN PHARMACOLOGY, 10.

Hoskin, R. T., Xiong, J., Esposito, D. A., & Lila, M. A. (2019). Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration. FOOD CHEMISTRY, 280, 187–194.

Grace MH, Xiong J, Esposito D, Ehlenfeldt M and Lila MA (2019). Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities. Food Chemistry 277, 336-346

Velde, F., Esposito, D., Grace, M. H., Pirovani, M. E., & Lila, M. A. (2019). Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits. FOOD RESEARCH INTERNATIONAL, 121, 453–462.

Velde, F., Esposito, D., Overall, J., Mendez-Galarraga, M. P., Grace, M., Piroyani, M. E., & Lila, M. A. (2019). Changes in the bioactive properties of strawberries caused by the storage in oxygen- and carbon dioxide-enriched atmospheres. FOOD SCIENCE & NUTRITION.

Xiong J, Overall J, Komarnytsky S, Esposito D. (2019). Dietary supplementation with anthocyanin-rich berries promotes healthy muscle development gene expression profiles in diet-induced obese mice. In Vitro Cellular & Developmental Biology-Animal (Vol. 55, pp. S26-S27). 233 SPRING ST, NY 10013 USA: SPRINGER.

Hoskin RT, Xiong J, Perkins-Veazie P, Esposito D (2019). Development of an efficient strategy to produce spray dried lycopene-rich watermelon-protein particles: In Vitro Evaluation of Phytochemicals and Skin Fibroblast Migration. In Vitro Cellular & Developmental Biology-Animal (Vol. 55, pp. S52-S52). 233 SPRING ST, NY 10013 USA: SPRINGER.

Esposito LG, Overbaugh E, Xiong J, Rathinasabapathy T, Komarnytsky S, Esposito D. (2019). Comparative anti-inflammatory activity of whole root, stem, leaf, and flower extracts from female and male CBD hemp (Cannabis sativa L.) Plants. In Vitro Cellular & Developmental Biology-Animal (Vol. 55, pp. S72-S73). 233 SPRING ST, NY 10013 USA: SPRINGER.

Bonney S, Wilson M, Xiong J, Raines D, Esposito D (2019). Protective Effects of Brassica Extracts in an Aging Rodent Model. 2019 IN VITRO BIOLOGY MEETING. LATE SUBMISSION ABSTRACTS (pp.8-9). June 8 – 12, 2019. Tampa, Florida

Overall J, Esposito D, Grace M, Komarnytsky S, and Lila MA (2019). Alaskan Wild Berry Extracts Promote Skin Repair and Attenuate Inflammatory Response In Vitro. IN VITRO BIOLOGY MEETING. LATE SUBMISSION ABSTRACTS (pp. 22-23). June 8 – 12, 2019. Tampa, Florida


Velde, F. V. , Esposito, D. , Pirovani, M. E. , Lila, M. A. (2018). In vitro Study of Inflammatory Gene Expression Suppression of Strawberry and Blackberry Extracts. World Academy of Science, Engineering and Technology, International Science Index, Nutrition and Food Engineering, 12(5), 1230.

Skates, E., Overall, J., DeZego, K., Wilson, M., Esposito, D., Lila, M. A., & Komarnytsky, S. (2018). Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage.

Nieman DC, Gillitt ND, Sha W, Esposito D, Ramamoorthy S. (2018)  Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial. PLoS One. 2018 Mar 22;13(3):e0194843. DOI: 10.1371/journal.pone.0194843. eCollection 2018. PMID: 29566095


Bussler, W. W., Dezego, K., Bowen, M., Buige, A., Esposito, D., Lila, M. A., & Komarnytsky, S. (2017). Health modifying regions in the oat (avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health. The FASEB Journal, 31(1), 437.7.

Correia, R., Grace, M. H., Esposito, D., & Lila, M. A. (2017). Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage.

Jackson, K. M. P., Rathinasabapathy, T., Bonney, S., Esposito, D., & Komarnytsky, S. (2017). Bitter receptors control glucose absorption in the gut by modifying the G-protein coupled receptor signaling cascade. The FASEB Journal, 31(1), 646.58. DOI:10.1096/fasebj.31.1_supplement.646.58

Jackson, K. M. P., Rathinasabapathy, T., Esposito, D., & Komarnytsky, S. (2017). Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory. Molecular Nutrition & Food Research, 61(9), 1601118.

Walter, K. R., Xi, L., Jacobi, S. K., Esposito, D., & Odle, J. (2017). Dietary long-chain PUFAs enrich porcine alveolar macrophages and alter prostaglandin E2 production following LPS challenge. The FASEB Journal, 31(1), 964.12.

Xiong, J., Grace, M.H., Esposito, D., Komarnytsky, S., Wang, F., & Lila, M.A. (2017). Polyphenols isolated from acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities.

Rathinasabapathy, T., Jackson, K.M.P, Thor, Y., et al. (2017). Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity. Journal of Chemistry, vol. 2017, Article ID 3182129, 10 pages, 2017. DOI://

Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., Lila, M., et al. (2017). Metabolic Effects of Berries with Structurally Diverse Anthocyanins. International Journal of Molecular Sciences, 18(2), 422. DOI://


Grace, M.H.,  Esposito, D., Timmers, M.A., Xiong, J., Yousef, G., Komarnytsky S., and Lila, M.A. (2016). In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food Funct., 2016, 7, 4285.

Komarnytsky S, Overall J, Wilson M, Esposito D (2016) Diverse bioenergetic profiles of M1/M2 macrophages exposed to anthocyanins and their phenolic metabolites. FASEB J April 30: 1169.9

Grace MH, Esposito D, Xiong J, Timmers M, Komarnytsky S, Lila MA (2016) Bioactive components from pistachios reduce adipogenesis and suppress inflammatory gene expression in vitro. FASEB J 30: 1176.16

Bussler W, Alley J, Chandler H, Thetford C, Yousef G, Brown A, Esposito D, Lila MA, Komarnytsky S (2016) Mapping inflammation and cancer-modifying regions in broccoli genome. FASEB J 30: 131.8

Palatini K. M., Durand P.J., Rathinasabapathy T., Esposito D., & Komarnytsky, S. (2016). Bitter receptors and glucose transporters interact to control carbohydrate and immune responses in the gut. FASEB J. 30, 682.6–682.6.

Van de Velde, Franco, Grace MA, Esposito D, Piovani ME, Lila MA. (2016) Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina. Journal of Food Composition and Analysis 47:82-91.

Schneider M, Esposito D, Lila MA, Foegeding EA (2016) Formation of whey protein-polyphenol meso-structures as a natural means of creating functional particles. Food Funct. 2016 Mar;7(3):1306-18. DOI: 10.1039/c5fo01499a.PMID: 26857696

Grace MH, Esposito D, Timmers MA, Xiong J, Yousef G, Komarnytsky S, Lila MA (2016) Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chem. 2016 Nov 1;210:85-95. DOI: 10.1016/j.foodchem.2016.04.088.PMID: 27211624

Xiong J, Graceb MH, Esposito D, Wang F, Lila MA (2016) Phytochemical Characterization and Anti-inflammatory Properties of Acacia mearnsii Leaves. Nat Prod Commun. 2016 May;11(5):649-53.PMID: 27319141.


Palatini K, Wilson M, Alley J, Esposito D, Komarnytsky S (2015) Diverse classes of bitter phytochemicals modulate carbohydrate metabolism and immune responses through gastrointestinal bitter taste receptors. FASEB J 29: 405.5

Konda V, Swick A, Troup JD, Montalto MB, Wilson M, Heidt K, Desai A, Esposito D, Komarnytsky S (2015) Efficacy of Rheum rhaponticum ERr 731 extract in alleviating vasomotor menopausal symptoms in an ovariectomized rat model. Menopause 21(12): 1337 (P-11)

Ricciardi CJ, Bae J, Esposito D, Komarnytsky S, Hu P, Chen J, Zhao L (2015) 1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Eur J Nutr. 54(6):1001-12. PMID: 25296887.

Graf, B, Cheng DM, Esposito D, Shertel T, Poulev A, Plundrich N, Itenberg D, Dayan N, Lila MA,  Raskin I (2015). Compounds leached from quinoa seeds inhibit matrix metaloproteinase activity and intracellular reactive oxygen species. Int. J. Cosmetic Sci. Apr.;37(2):212-21.

Kellogg J, Esposito D, Komarnytsky S, Grace MH, Lila MA (2015) Alaskan seaweeds lower inflammation in raw 264.7 macrophages and decrease lipid accumulation in 3T3L1 adipocytes. Journal of Functional Foods, 15(2015):396-407.

Esposito D, Damsud T, Wilson M, Grace MH, Strauch R, Li X, Lila MA, Komarnytsky S (2015) Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome. Journal of Agricultural and Food Chemistry, 15;63(27):6172-80. Selected as ACS Editors’ Choice due to its potential for broad public interest.

Tang W, Munafo JP Jr, Palatini K, Esposito D, Huang MT, Komarnytsky S, Ho CT, Gianfagna TJ (2015) Hepatoprotective Activity of Easter Lily (Lilium longiflorum Thunb.) Bulb Extracts. J Agric Food Chem. 2015 Nov 11;63(44):9722-8.

Timmers MA, Guerrero-Medina JL, Esposito D, Grace MH, Paredes-López O, García-Saucedo PA, Lila MA. (2015) Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit.  J Agric Food Chem. 2015 Dec 9;63(48):10459-65. DOI: 10.1021/acs.jafc.5b04781PMID: 26575200


Ricciardi C, Bae J, Hu P, Esposito D, Komarnytsky S, Chen J, Zhao L (2014) 1, 25-Dihydroxyvitamin D3/Vit D receptor suppresses brown adipocyte differentiation and mitochondrial biogenesis. FASEB J 28: 1041.6.

Kellogg J, Esposito D, Komarnytsky S, Lila MA (2014) Anti-inflammatory bioactives in Alaskan seaweed: implications in metabolic syndrome. FASEB J 28: 1045.14.

Komarnytsky S, Chen A, Thor Y, Palatini K, Wilson M, Esposito D (2014) Bioenergetic characterization of macrophage inflammatory responses attenuated by anthocyanins. FASEB J 28: 383.2.

Grace MH, Esposito D, Dunlap KL, Lila MA. (2014) Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. Journal of Agricultural and Food Chemistry 62(18), 4007–4017.

Esposito D, Chen A, Grace MH, Komarnytsky S, Lila MA (2014) Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro. Journal of Agricultural and Food Chemistry 62(29):7022-7028.

Bae J, Ricciardi CJ, Esposito D, Komarnytsky S, Hu P, Curry BJ, Brown PL, Gao Z, Biggerstaff JP, Chen J, Zhao L (2014) Activation of pattern recognition receptors in brown adipocytes induce inflammation and suppress uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol, 306(10):C918-30.

Le V, Esposito D, Grace MH, Ha D, Pham A, Bortolazzo A, Bevens Z, Kim J, Okuda R, Komarnytsky S, Lila MA, White JB. (2014).  Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells.  Nutrition and Cancer:  66(8):1304-1314.

Grace MH, Yousef GG, Esposito D, Raskin I, Lila MA (2014) Bioactive capacity, sensory properties, and nutritional analysis of a shelf stable protein-rich functional ingredient with concentrated fruit and vegetable phytoactives.  Plant Foods for Human Nutrition 69(4):372-378.


Grace MH, Neff SA, Warlick C, Ayoub E, Esposito D, Wilson M, Komarnytsky S, Lila MA (2013) HSCCC isolation and characterization of walnut polyphenols with antioxidative and lipolytic activity. FASEB J 27: 1065.17.

Esposito D, Wilson M, Holway H, Komarnytsky S (2013) Bioenergetic characterization of adipogenesis impaired by inflammation. FASEB J 27: 109.4.

Wilson M, Esposito D, Seale T, MacRae S, Venter S, Komarnytsky S (2013) Biofilm formation and cell invasion among environmentally persistent Escherichia coli isolates from South Africa watersheds. J Food Protection 76(SA): 50

Esposito D, Rathinasabapathy T, Schmidt B,Shakarjian MP, Komarnytsky S, Raskin I. (2013) Acceleration of cutaneous wound healing by brassinosteroids. Journal of Wound Rep Regen, 21(5): 688 – 696.

Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ. (2013) Steroidal Glycosides from the Bulbs of Easter Lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. Journal of Ethnopharmacology 148(2):433-440.

Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I (2013) Effects of pregnane glycosides on food intake depend on stimulation of melanocortin pathway and BDNF in animal model. J. Agric. Food Chem. 61(8): 1841−1849.

Komarnytsky S, Esposito D, Poulev A, Raskin I. (2013) Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. J. Cell. Physiol., 228(5): 1120–1126.


Esposito, D., Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2012). Hypoglycemic effects of brassinosteroid in diet-induced obese mice. American Journal of Physiology-Endocrinology and Metabolism, 303(5), E658.

Esposito D, Komarnytsky S, Kizelsztein P, Raskin I (2012) Brassinosteroid decreases hyperglycemia in a diet-induced obesity mouse model. Pharmaceut Biol 50(5): 597

Huang J, Esposito D, Kizelsztein P, Raskin I, Komarnytsky S (2012) Triptolide ameliorates insulin resistance in obese diabetic mice. Pharmaceut Biol 50(5): 644

Esposito D, Tuazon M, Henderson GC, Komarnytsky S, Raskin I (2012) Brassinosteroid enhances C57BL/6J mice treadmill endurance. FASEB J 26: 1121.8.

Komarnytsky S, Esposito D, Raskin I (2012) In vivo mouse model for examining contribution of inflammation to development of obesity and diabetes. FASEB J 26: 364.4.

Esposito D, Raskin I, Komarnytsky S (2012) Homobrassinolide enhances myogenic potential of satellite muscle cells. In Vitro Cell Develop Biol Animal 48(S1): S31

Esposito D, Holway H, Komarnytsky S (2012) Stimulation of muscle growth and carbohydrate metabolism genes by dietary brassinosteroids. J Nutrigenet Nutrigenomics 5: 220

Wilson M, Esposito D, Komarnytsky S (2012) Nutrigenetic interaction between uncoupling proteins and dietary plant ssteroids alters energy metabolism. J Nutrigenet Nutrigenomics 5: 284

Esposito D, Kizelsztein P, Komarnytsky S, Raskin I. (2012) Hypoglycemic effects of brassinosteroid in diet-induced obese mice. Am J Physiol Endocrinol Metab, 303(5): E652-E658.


Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I (2011) Brassinosteroids increase protein accumulation in skeletal muscle cells. In Vitro Cell Develop Biol Animal 47(S1): S38

Esposito D, Rathinasabapathy T, Poulev A., Komarnytsky S, Raskin I. (2011) Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Medicinal Chemistry, 54(12): 4057–4066.

Esposito D, Komarnytsky S, Shapses S, Raskin I. (2011) Anabolic effect of plant brassinosteroid. FASEB J, 25(10): 3708-19.


Alves-Júnior M, Alfenas-Zerbini P, Andrade EC, Esposito DA, Silva FN, da Cruz ACF, Ventrella MC, Otoni WC, Zerbini FM. (2009). Synergism and negative interference during co-infection of tomato and Nicotiana benthamiana with two bipartite begomoviruses. Virology, 387(2): 257-66.


Govorko D, Logendra S, Wang Y, Esposito D et al (2007) Polyphenolic compounds from Artemisia dracunculus inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab, 293(6):E1503-1510.